Our lab strives to improve reproductive outcomes and child health through cutting-edge research in virology, microbiology, molecular biology and genomics. Our focus is on understanding the complex interactions between the vaginal microbiome/virome, maternal immune response and reproductive outcomes, which are essential for advancing maternal-fetal health.
Our research involves the longitudinal analysis of human samples over the course of pregnancy to compare the vaginal bacterial communities and maternal host responses in those who deliver preterm versus term. Utilizing both in vitro cell culture and in vivo mouse models of viral infection, we seek to uncover the mechanisms by which pregnancy-induced physiological changes impact and are impacted by viral infections.
By considering both microbial presence and host immune response, we aim to gain deeper insights into maternal-microbe interactions. Ultimately, our goal is to identify biomarkers and potential mechanisms for preterm birth, leading to better predictive and preventive strategies for maternal and child health.
Training opportunities
Opportunities for postdocs, DBBS graduate students, and undergraduate students are available. If interested, contact Kristine Wylie.
